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Increased risk of adverse pregnancy outcomes in women with Rheumatoid Arthritis: a nationwide population-based study
Type
article
Resource
Annals of the rheumatic diseases. 69(4): 715-717.
Date Issued
2009-04-29
Author(s)
Lin,Herng-Ching; Chen,Shu-Fen; 林秀真; Chen,Yi-Hua
Subjects
小兒學科
Abstract
Objective: Using a three-year nationwide population-based database (2001-2003), this
study aims to examine the relationship between rheumatoid arthritis (RA) and adverse
pregnancy outcomes, after adjusting for characteristics of infant, mother and father.
Methods: The study used the Taiwan National Health Insurance Research Dataset and birth
certificate registry. In total, 1,912 mothers with RA and 9,560 matched comparison mothers
were included for analysis. Separate conditional logistic regression analyses were carried out
to explore the risk of low birthweight (LBW), preterm births, small for gestational age
(SGA) infants, preeclampsia, and delivery mode (vaginal vs. cesarean section (CS)) for the
study and comparison groups, after adjusting for potential confounders.
Results: Regression analyses showed that the adjusted odds of LBW, SGA infants,
preeclampsia, and CS for women with RA were 1.47 (95% CI=1.22-1.78), 1.20 (95%
CI=1.05-1.38), 2.22 (95% CI=1.59-3.11), and 1.19 (95% CI=1.07-1.31) times, respectively,
that of comparison mothers.
Conclusion: After adjusting for potential confounding factors, women with RA had
increased risk of LBW, SGA babies, preeclampsia, and CS, compared with unaffected
women. Our findings suggest a need for active monitoring and early intervention to counter
the increased risk of adverse obstetric outcomes for pregnant women with RA.
study aims to examine the relationship between rheumatoid arthritis (RA) and adverse
pregnancy outcomes, after adjusting for characteristics of infant, mother and father.
Methods: The study used the Taiwan National Health Insurance Research Dataset and birth
certificate registry. In total, 1,912 mothers with RA and 9,560 matched comparison mothers
were included for analysis. Separate conditional logistic regression analyses were carried out
to explore the risk of low birthweight (LBW), preterm births, small for gestational age
(SGA) infants, preeclampsia, and delivery mode (vaginal vs. cesarean section (CS)) for the
study and comparison groups, after adjusting for potential confounders.
Results: Regression analyses showed that the adjusted odds of LBW, SGA infants,
preeclampsia, and CS for women with RA were 1.47 (95% CI=1.22-1.78), 1.20 (95%
CI=1.05-1.38), 2.22 (95% CI=1.59-3.11), and 1.19 (95% CI=1.07-1.31) times, respectively,
that of comparison mothers.
Conclusion: After adjusting for potential confounding factors, women with RA had
increased risk of LBW, SGA babies, preeclampsia, and CS, compared with unaffected
women. Our findings suggest a need for active monitoring and early intervention to counter
the increased risk of adverse obstetric outcomes for pregnant women with RA.