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  5. 甲基類固醇與紅血球生成素對脊髓損傷的影響:生物晶片資料分析
 
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甲基類固醇與紅血球生成素對脊髓損傷的影響:生物晶片資料分析

Other Title
The influence of Methylprednisolone and Erythropoietin to spinal cord injury:microarray data analysis
Type
thesis
Date Issued
2009-06-22
Author(s)
蔡孟瑜
Advisor
李元綺
Subjects
系所名稱:醫學資訊研究所
Description
學位別:碩士
語文別:中文
指導教授:李元綺
共同指導教授:
口試委員:楊良友;徐建業;陳光琦;鍾翊方
中文關鍵字:甲基類固醇;紅血球生成素;生物晶片;脊髓損傷;基因表現
Abstract
在藥物MP與EPO治療對於脊髓損傷的研究中,顯示藥物MP有極大的副作用,雖然對於急性期的脊髓損傷治療有幫助,但長期使用會造成很多後遺症;藥物EPO對於脊髓損傷恢復已有動物實驗證實比藥物MP更好並且它的副作用較少。我們發現脊髓損傷的相關機制仍然有許多不是很清楚,臨床上真正有助於恢復的藥物也尚未找到。故我們希望能全面性地了解脊髓損傷的基本反應機制、分別再進一步地探討藥物MP與EPO對脊髓損傷的反應機制。我們將設計不同的時間點,在時間序列上檢視基因表現量的變化,希望可以區分出藥物MP與EPO對於脊髓損傷反應基因的類型,綜觀這些反應基因群,我們將以生物網絡的方式呈現,提供對於脊髓損傷的反應機制更深入的剖析。
URI
https://203.71.86.71/handle/123456789/13017
https://hdl.handle.net/11296/swz2m3
File(s)
No Thumbnail Available
Name

C0191271.pdf

Size

27.67 MB

Format

Adobe PDF

Checksum

(MD5):8e0fe0cd28381be78cbc752bb322d3f2

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