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  5. 利用生醫文獻探勘技術擷取微型核糖核酸誘導之癌症轉移關聯網路
 
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利用生醫文獻探勘技術擷取微型核糖核酸誘導之癌症轉移關聯網路

Other Title
MicroRNA-induced Metastasis Network Construction via Text Mining Techniques
Type
thesis
Date Issued
2016-07-12
Author(s)
顧云菂
Advisor
蘇家玉
戴鴻傑
Subjects
系所名稱:醫學資訊研究所
Description
學位別:碩士
語文別:中文
指導教授:蘇家玉
共同指導教授:戴鴻傑
口試委員:李友專;蔣以仁;蔡宗翰
中文關鍵字:文獻探勘;微型核醣核酸;癌症轉移
英文關鍵字:Text Mining;MicroRNA;Metastasis
Abstract
微型核糖核酸 (microRNA,簡稱 miRNA) 是由去氧核醣核酸 (Deoxyribonucleic acid,簡稱 DNA)轉錄而來,但無法轉譯成蛋白質的一種小分子 RNA。miRNA 透過訊息核糖核酸(Message RNA,簡稱 mRNA)裂解或轉錄抑制來調控 mRNA,促使基因轉譯為蛋白質。近期有許多研究指出,當 miRNA 發生錯誤調控時,可能會引發細胞分裂失控之現象而造成癌症的發生或是癌症轉移的現象。因此,miRNA 可被視為致癌或抑癌的關鍵角色,以致相關文獻大量產生。因此,本研究希望可以開發出 miRNA 名稱辨識系統,結合現有的疾病名辨識結果來自動化的從生醫文獻中擷取提及之 miRNA 及癌症轉移相關訊息,最後依據得到的結果建立出一個 miRNA 影響癌症轉移的關聯網路圖,讓相關研究者能夠藉由本系統所產生的結果,快速的了解現階段在文獻中提及各 miRNA 影響癌症轉移的情況與相關參考文獻。
URI
https://203.71.86.71/handle/123456789/57618

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