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  5. 抗沾黏奈米表面改質於微創電外科設備之臨床腦癌手術分析
 
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抗沾黏奈米表面改質於微創電外科設備之臨床腦癌手術分析

Other Title
Research of anti-sticking nanostructured surface modification on
minimally invasive electrosurgery devices
Type
thesis
Date Issued
2014-12-22
Author(s)
邱欣達
Advisor
程瀚毅
Subjects
系所名稱:醫療器材產業碩士專班
Description
學位別:碩士
語文別:英文
指導教授:程瀚毅
共同指導教授:
口試委員:黃瓊芳;劉沖明
中文關鍵字:組織工程;抗沾黏;類鑽碳薄膜
英文關鍵字:biomedical nanostructured coating;electrosurgery;thermal injury
Abstract
於電燒手術時,熱損傷與組織沾黏將會影響傷口之癒合速度。本研究的目的是用
一類鑽碳(DLC-Cu)的表面處理技術應用於微創電外科儀器,觀察於腦手術時
之熱損傷。本研究將採用掃描電子顯微鏡和透射電子顯微鏡於DLC-Cu 薄膜的表
面進行形貌之觀察。並藉由核磁共振影像建立三維腦模型模擬電切手術之過程。
在動物模型中,將比較未處理的不銹鋼(SS)以及DLC-Cu-SS 之電燒手術裝置。
在術後之0、2、7 以及28 天犧牲大鼠,做組織切片之評估。數據表明使用電外
科用奈米結構DLC 薄膜之電燒器械時溫度顯著降低,並且溫度將隨著膜厚度增
加而減少。在動物模型中,熱成像顯示未經處理的器械溫度較DLC-Cu 電燒刀溫
度高。此外,DLC-Cu-SS 電燒刀創建一個相對小的熱損傷區域。這些結果顯示
DLC 薄膜可減少過度熱損傷,並且在大腦中均勻分佈的溫度。
URI
https://203.71.86.71/handle/123456789/57278

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