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Global Prevalence and Moderating Factors of Swallowing Disorder Among Older Adults with Different Subtypes of Dementia: A Meta-Analysis
Type
thesis
Date Issued
2024-06-20
Author(s)
ALFIANI RAHMI PUTRI
Advisor
周桂如
Subjects
系所名稱：護理學系碩士班
Publisher
護理學系碩士班
Description
學位別：碩士
關鍵字：Swallowing disorder; Dysphagia; Dementia; Meta-Analysis
論文公開日期：2024-06-27
關鍵字：Swallowing disorder; Dysphagia; Dementia; Meta-Analysis
論文公開日期：2024-06-27
Abstract
Background: The aging process and abnormal protein accumulation in dementia damage neural pathways affecting the swallowing process, and leading to swallowing disorder.
Objective: To estimate the global prevalence of swallowing disorder among older adults with different dementia subtypes.
Methods: We systematically searched PubMed, Embase, Scopus, Web of Science, and OVID-Medline. Using R (version 4.0.2) and GLMM with a random-effect model, we estimated the pooled prevalence of swallowing disorder in older adults with dementia. Study quality was assessed with Hoy's criteria, and heterogeneity was evaluated using Cochrane's Q and I² statistics. Moderator analysis was conducted to identify variables contributing to heterogeneity.
Results: 23 studies with 13,042 older adults with different dementia subtypes were enrolled in our meta-analysis. The global prevalence of swallowing disorder among older adults with dementia was 59.0%, with 46.3% for Alzheimer's dementia, 34.9% for Parkinson's dementia, 18.8% for vascular dementia, 16.3% for mixed dementia, and 12.2% for Lewy-body dementia. According to the assessment tools, the prevalence of swallowing disorder had the highest using instrumental assessments at 70.3%, followed by EAT-10 at 60.6%, and the clinical assessments at 50.2%. Alzheimer’s dementia, moderate-to-severe dementia, moderate MMSE, medical history, delayed oral phase, delayed pharyngeal phase, and poor tongue motility contributed to the high prevalence of swallowing disorder.
Conclusions: More than half of older adults with dementia demonstrate to have a swallowing disorder. Our findings offer valuable insights to healthcare professionals for the identification of swallowing disorder in the aging population with dementia.
Objective: To estimate the global prevalence of swallowing disorder among older adults with different dementia subtypes.
Methods: We systematically searched PubMed, Embase, Scopus, Web of Science, and OVID-Medline. Using R (version 4.0.2) and GLMM with a random-effect model, we estimated the pooled prevalence of swallowing disorder in older adults with dementia. Study quality was assessed with Hoy's criteria, and heterogeneity was evaluated using Cochrane's Q and I² statistics. Moderator analysis was conducted to identify variables contributing to heterogeneity.
Results: 23 studies with 13,042 older adults with different dementia subtypes were enrolled in our meta-analysis. The global prevalence of swallowing disorder among older adults with dementia was 59.0%, with 46.3% for Alzheimer's dementia, 34.9% for Parkinson's dementia, 18.8% for vascular dementia, 16.3% for mixed dementia, and 12.2% for Lewy-body dementia. According to the assessment tools, the prevalence of swallowing disorder had the highest using instrumental assessments at 70.3%, followed by EAT-10 at 60.6%, and the clinical assessments at 50.2%. Alzheimer’s dementia, moderate-to-severe dementia, moderate MMSE, medical history, delayed oral phase, delayed pharyngeal phase, and poor tongue motility contributed to the high prevalence of swallowing disorder.
Conclusions: More than half of older adults with dementia demonstrate to have a swallowing disorder. Our findings offer valuable insights to healthcare professionals for the identification of swallowing disorder in the aging population with dementia.