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  5. 鈦金屬表面形貌對骨母細胞型態之影響
 
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鈦金屬表面形貌對骨母細胞型態之影響

Other Title
The effect of Ti surface morphology on the adhesion behavior of osteoblast-like cells
Type
thesis
Date Issued
2013-12-14
Author(s)
謝宗龍
Advisor
施永勳
Subjects
系所名稱:醫療器材產業碩士專班
Description
學位別:碩士
語文別:英文
指導教授:施永勳
共同指導教授:
口試委員:歐士輔;周幸華
中文關鍵字:陽極氧化;有限元素分析;應力
Abstract
體外細胞反應被認為與基質的物理和化學性質有關聯。本研究中對不同化學組成和表面型態基質的鈦金屬表面進行MG- 63成骨細胞貼附評估,針對在鈦金屬表面不同處理:機械加工的孔洞與凹槽(control)、陽極氧化處理(AO)和陽極氧化伴隨水熱處理(HYT)三種類型。細胞貼附在經陽極氧化處理和陽極氧化伴隨水熱處理的表面於5小時後展現良好的伸展特性,將歸因於其化學因素,例如:
在表面包含鈣和磷。經24小時後,細胞完整平貼在經陽極氧化伴隨水熱處理的表面,但在只經陽極氧化處理的表面則沒有此效果,這說明提高細胞貼附行為還有物理因素,於特定表面形貌提供了細胞比較大的機械性刺激。進一步利用有限元方法評估細胞的應力分佈(P > 0.01 ),根據數據說明,對於經陽極氧化伴隨水熱處理的組別,細胞相較於其他表面處理接受到較大的應力刺激。
URI
https://203.71.86.71/handle/123456789/56953

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