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Relationships between Serum Iron Biomarkers, Body Composition and Advanced Glycation End Products (AGEs) in Predicting Fatty Liver Severity
Other Title
Relationships between Serum Iron Biomarkers, Body Composition and Advanced Glycation End Products (AGEs) in Predicting Fatty Liver Severity
Type
thesis
Date Issued
2017-06-30
Author(s)
Nindy Sabrina
Advisor
張榮素
Subjects
系所名稱：保健營養學研究所
Description
學位別：碩士
語文別：英文
指導教授：張榮素
口試委員：白其卉;莊紹源
中文關鍵字：Non-alcoholic fatty liver disease;Advanced glycation end products, Serum iron biomarkers, Body composition
英文關鍵字：Non-alcoholic fatty liver disease;Advanced glycation end products, Serum iron biomarkers, Body composition
語文別：英文
指導教授：張榮素
口試委員：白其卉;莊紹源
中文關鍵字：Non-alcoholic fatty liver disease;Advanced glycation end products, Serum iron biomarkers, Body composition
英文關鍵字：Non-alcoholic fatty liver disease;Advanced glycation end products, Serum iron biomarkers, Body composition
Abstract
Background: Dysregulated iron metabolism and the advanced glycation end products (AGEs) are linked to non-alcoholic fatty liver disease (NAFLD). The aims were to investigate: (1) relationships between serum iron biomarkers, Nε-(carboxymethyl) lysine (CML) and fatty liver severity; (2) relationships between iron biomarkers, dietary pattern, body composition and fatty liver severity among adult women.
Methods: NAFLD was diagnosed based on abdominal ultrasonography. In total, 250 Taiwanese adults (49 controls and 201 NAFLD) were selected for analysis.
Results: The prevalence rate of NAFLD from general participant was 80.4%. Aim 1: (1) Spearmen’s correlation analysis showed that serum CML was positively correlated with soluble (s) CD163 but negatively correlated with free hemoglobin (Hb). Interactive analysis showed that sCD163 levels influence the relationship between serum free Hb and serum CML; (2) Multivariate linear regression analysis showed that serum free Hb [ß = -1.1 (-1.4--0.74); p < 0.0001] and sCD163 [ß = 0.053 (0.01-0.09); p < 0.05] were independent predictors of serum CML. Interactive analysis showed that, compared with individuals with the lowest serum free Hb and CML median (M1, Reference), individuals with the highest serum CML and free Hb (M2) had 6.86 times [OR = 6.86, 95% (1.85-125.4); p = 0.004] times highest risk for NAFLD; Aim 2: (3) Adjusted linear regression analysis showed that among young adult women (<45 yrs), one unit increased in serum iron to ferritin ratio was associated with 0.687 percentage (%) increased in skeletal muscle mass and 0.159% decreased in visceral fat (all p = 0.002). No differences were found in middle-aged women (≥45 yrs); (4) Adjusted logistic regression analysis showed that serum iron to ferritin ratio was associated with 47% reduced odds of progression from mild to moderate/severe fatty liver among young adult women [OR = 0.53 (0.298-0.946); p < 0.05]; Increased consumption of beef and lamb, dairy products, fruits and whole grain and decreased consumption of refined carbohydrate (rice, noodles, bread and pastry), deep-fry and stir-fry foods may protect young women against severe fatty liver injury [OR = 0.10 (0.02-0.47); p < 0.001].
Conclusion: The interaction between sCD163-free Hb and CML may underlie the etiology and progression of NAFLD. The iron to ferritin ratio predicts healthy body composition and lower risk of severe fatty liver progression in young adult women.
Keywords: Non-alcoholic fatty liver disease, Advanced glycation end products, Serum iron biomarkers, Body composition
Methods: NAFLD was diagnosed based on abdominal ultrasonography. In total, 250 Taiwanese adults (49 controls and 201 NAFLD) were selected for analysis.
Results: The prevalence rate of NAFLD from general participant was 80.4%. Aim 1: (1) Spearmen’s correlation analysis showed that serum CML was positively correlated with soluble (s) CD163 but negatively correlated with free hemoglobin (Hb). Interactive analysis showed that sCD163 levels influence the relationship between serum free Hb and serum CML; (2) Multivariate linear regression analysis showed that serum free Hb [ß = -1.1 (-1.4--0.74); p < 0.0001] and sCD163 [ß = 0.053 (0.01-0.09); p < 0.05] were independent predictors of serum CML. Interactive analysis showed that, compared with individuals with the lowest serum free Hb and CML median (M1, Reference), individuals with the highest serum CML and free Hb (M2) had 6.86 times [OR = 6.86, 95% (1.85-125.4); p = 0.004] times highest risk for NAFLD; Aim 2: (3) Adjusted linear regression analysis showed that among young adult women (<45 yrs), one unit increased in serum iron to ferritin ratio was associated with 0.687 percentage (%) increased in skeletal muscle mass and 0.159% decreased in visceral fat (all p = 0.002). No differences were found in middle-aged women (≥45 yrs); (4) Adjusted logistic regression analysis showed that serum iron to ferritin ratio was associated with 47% reduced odds of progression from mild to moderate/severe fatty liver among young adult women [OR = 0.53 (0.298-0.946); p < 0.05]; Increased consumption of beef and lamb, dairy products, fruits and whole grain and decreased consumption of refined carbohydrate (rice, noodles, bread and pastry), deep-fry and stir-fry foods may protect young women against severe fatty liver injury [OR = 0.10 (0.02-0.47); p < 0.001].
Conclusion: The interaction between sCD163-free Hb and CML may underlie the etiology and progression of NAFLD. The iron to ferritin ratio predicts healthy body composition and lower risk of severe fatty liver progression in young adult women.
Keywords: Non-alcoholic fatty liver disease, Advanced glycation end products, Serum iron biomarkers, Body composition