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ASSOCIATION OF HEPATITIS B VIRUS INFECTION WITH CHRONIC KIDNEY DISEASE IN UNIVERSITY STUDENTS UNDERGOING HEALTH EXAMINATION
Other Title
ASSOCIATION OF HEPATITIS B VIRUS INFECTION WITH CHRONIC KIDNEY DISEASE IN UNIVERSITY STUDENTS UNDERGOING HEALTH EXAMINATION
Type
thesis
Date Issued
2012-06-25
Author(s)
THOMAS SENGHORE
Advisor
葉志清
Subjects
系所名稱：醫務管理學研究所
Publisher
醫務管理學研究所
Description
學位別：碩士
語文別：英文
指導教授：葉志清
共同指導教授：
口試委員：宋鴻樟;謝玲玲
中文關鍵字：Taiwan;university students;chronic kidney disease;hepatitis B virus;gender-different risk
語文別：英文
指導教授：葉志清
共同指導教授：
口試委員：宋鴻樟;謝玲玲
中文關鍵字：Taiwan;university students;chronic kidney disease;hepatitis B virus;gender-different risk
Abstract
Introduction
Taiwan is prevalent of chronic kidney disease (CKD) and an endemic area for chronic hepatitis B virus infection (HBV). There is still inconsistent evidence showing the relationship between CKD and HBV. The cross-sectional study aims to investigate this association among university freshmen in Taiwan.
Methods
Data from health check-ups for 7,745 university entrants in 2000 – 2001 at a northern university was obtained for this study. Using the modification of diet in renal disease (MDRD) study equation, the estimated glomerular filtration rate (eGFR) was calculated. Odds ratios (ORs) and 95% confidence intervals (CIs) for the association between HBV and CKD were estimated by logistic regression.
Results
The prevalence of HBV and CKD were 7.4% and 6.8% respectively. The prevalence of HBV positive in CKD and non-CKD were not significant (6.0% versus 6.9%, p = 0.42). After adjusting for covariates, the logistic regression analysis for the association of HBV with CKD and low eGFR (<60 ml/min/1.73 m2) show an OR of 0.85 (95% CI = 0.60 – 1.23) and 0.60 (95% CI = 0.30 – 1.24) respectively. Further stratification by sex showed no significant difference with low eGFR. However, males showed an increased risk of CKD (OR = 1.23, 95% CI = 0.76 – 2.00), while females show a decreased risk of CKD (OR = 0.59, 95% CI = 0.34 – 1.02) (interaction test p = 0.06).
Conclusion
Our results did not support the hypothesis that HBV is associated with increased risk of CKD. Young HBV female carriers tend to possess a protective effect of developing CKD. However, the gender-different risk of CKD needs to be clarified in further larger sample size study.
Taiwan is prevalent of chronic kidney disease (CKD) and an endemic area for chronic hepatitis B virus infection (HBV). There is still inconsistent evidence showing the relationship between CKD and HBV. The cross-sectional study aims to investigate this association among university freshmen in Taiwan.
Methods
Data from health check-ups for 7,745 university entrants in 2000 – 2001 at a northern university was obtained for this study. Using the modification of diet in renal disease (MDRD) study equation, the estimated glomerular filtration rate (eGFR) was calculated. Odds ratios (ORs) and 95% confidence intervals (CIs) for the association between HBV and CKD were estimated by logistic regression.
Results
The prevalence of HBV and CKD were 7.4% and 6.8% respectively. The prevalence of HBV positive in CKD and non-CKD were not significant (6.0% versus 6.9%, p = 0.42). After adjusting for covariates, the logistic regression analysis for the association of HBV with CKD and low eGFR (<60 ml/min/1.73 m2) show an OR of 0.85 (95% CI = 0.60 – 1.23) and 0.60 (95% CI = 0.30 – 1.24) respectively. Further stratification by sex showed no significant difference with low eGFR. However, males showed an increased risk of CKD (OR = 1.23, 95% CI = 0.76 – 2.00), while females show a decreased risk of CKD (OR = 0.59, 95% CI = 0.34 – 1.02) (interaction test p = 0.06).
Conclusion
Our results did not support the hypothesis that HBV is associated with increased risk of CKD. Young HBV female carriers tend to possess a protective effect of developing CKD. However, the gender-different risk of CKD needs to be clarified in further larger sample size study.