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蠶絲蛋白離子水凝膠之人體運動感測應用
Other Title
Silk Fibroin-Based Ionotronic Hydrogels As Body Motion Sensors
Type
thesis
Date Issued
2025-06-16
Author(s)
吳育慈
Subjects
系所名稱：奈米醫學工程研究所碩士班
Publisher
奈米醫學工程研究所碩士班
Description
學位別：碩士
口試委員：楊正昌; 白台瑞; 彭姵雯; 蔡承育; 林群哲
關鍵字：Silk fibroin、Ionotronic hydrogel
口試委員：楊正昌; 白台瑞; 彭姵雯; 蔡承育; 林群哲
關鍵字：Silk fibroin、Ionotronic hydrogel
Abstract
Background: An ionotronic hydrogel is a type of soft, flexible material characterized by its intrinsic flexibility and ionic conductivity, holds great promise for applications in bioelectronics. Among various biosensing platforms, body motion sensors have garnered particular attention for their utility in healthcare monitoring, sports performance assessment, and human–machine interaction. Like traditional ionotronic hydrogels, polyvinyl alcohol/silk fibroin/borax hydrogel offer notable advantages such as stretchability, self-healing and tunable electrical properties, however their practical applications are limited by poor mechanical strength and long-term stability.
Aims: This study aims to enhance the mechanical properties and long-term stability of ionotronic hydrogels for body motion sensing by introducing an SF/CaCl₂ solution to overcome the limitations of conventional fabrication processes.
Material and Methods: This study focuses on the development of a composite hydrogel composed of polyvinyl alcohol (PVA) and silk fibroin (SF). Degummed silk fibroin was dissolved in a calcium chloride/ethanol/water solution and mixed with PVA to improve the stability of the hydrogel. The resulting composite hydrogels (PSC hydrogels) were systematically characterized using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). Additionally, evaluations were conducted for water retention, mechanical properties, strain response, and electrical resistance changes.
Results: Characterization of the synthesized PSC hydrogels demonstrated tunable structural and mechanical properties essential for sensing applications. FTIR analysis revealed that increasing PVA content influenced Amide I band shifts, suggesting altered hydrogen bonding interactions within the network. SEM images showed that higher CaCl₂ content resulted in larger pores, while increased PVA led to a denser microstructure. Stable water retention was achieved across different compositions. Mechanical tensile tests indicated exceptional stretchability, with samples S2 and S3 reaching approximately 500% strain and achieving tensile stresses of 4.8 MPa and 2.7 MPa.
Conclusions: This study developed physically crosslinked PVA/SF/CaCl₂ hydrogels with a simplified fabrication method that omits dialysis. The resulting hydrogels exhibited high stretchability and strong mechanical performance (4.8 MPa), along with stable water retention. Electrical testing confirmed consistent piezoresistive responses under cyclic strain, suitable for tensile motion sensing applications. These results demonstrate the potential of this hydrogel as a durable pressure and motion sensor material.
Aims: This study aims to enhance the mechanical properties and long-term stability of ionotronic hydrogels for body motion sensing by introducing an SF/CaCl₂ solution to overcome the limitations of conventional fabrication processes.
Material and Methods: This study focuses on the development of a composite hydrogel composed of polyvinyl alcohol (PVA) and silk fibroin (SF). Degummed silk fibroin was dissolved in a calcium chloride/ethanol/water solution and mixed with PVA to improve the stability of the hydrogel. The resulting composite hydrogels (PSC hydrogels) were systematically characterized using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). Additionally, evaluations were conducted for water retention, mechanical properties, strain response, and electrical resistance changes.
Results: Characterization of the synthesized PSC hydrogels demonstrated tunable structural and mechanical properties essential for sensing applications. FTIR analysis revealed that increasing PVA content influenced Amide I band shifts, suggesting altered hydrogen bonding interactions within the network. SEM images showed that higher CaCl₂ content resulted in larger pores, while increased PVA led to a denser microstructure. Stable water retention was achieved across different compositions. Mechanical tensile tests indicated exceptional stretchability, with samples S2 and S3 reaching approximately 500% strain and achieving tensile stresses of 4.8 MPa and 2.7 MPa.
Conclusions: This study developed physically crosslinked PVA/SF/CaCl₂ hydrogels with a simplified fabrication method that omits dialysis. The resulting hydrogels exhibited high stretchability and strong mechanical performance (4.8 MPa), along with stable water retention. Electrical testing confirmed consistent piezoresistive responses under cyclic strain, suitable for tensile motion sensing applications. These results demonstrate the potential of this hydrogel as a durable pressure and motion sensor material.