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  5. 視覺化基因分子調控路徑及基因附加資訊整合平台之建構
 
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視覺化基因分子調控路徑及基因附加資訊整合平台之建構

Other Title
Integrated Platform Construction of Gene Pathways Visualization and Gene Annotations
Type
thesis
Date Issued
2010-06-23
Author(s)
周畹萍
Advisor
李元綺
Subjects
系所名稱:醫學資訊研究所
Description
學位別:碩士
語文別:中文
指導教授:李元綺
共同指導教授:蔣以仁
口試委員:蘇嘉玉;蔡懷寬;Charles E. Cook
中文關鍵字:基因調控路徑;視覺化;基因注釋;基因整合資訊
Abstract
隨著基因調控研究的開展,基因調控網絡視覺化的重要性越來越受到重視,基因存在著彼此調控的機制,透過其所製造出來具有功能性的蛋白質,作為轉錄因子黏附到其目標基因,目標基因便會接收轉錄因子所帶來的訊號,進行基因的活化或抑制,並進而產生功能性蛋白質,供給生物體內的運作的需求,亦或是再成為轉錄因子,調控位於更下游的基因。而這一連串的過程,我們即可繪製出基因調控的路徑,透過視覺化工具的繪製,便能將抽象的基因調控網路具體化,透過直覺式的圖形化呈現,便能更快速掌握基因調控的相關情形。

本研究本著協助使用者提升使用效率的想法概念,以基因調控路徑視覺化為目標,結合近年來的Flex新技術,利用其開發友善的使用者圖形化介面之強項,規劃建構出一套整合性平台,以開發路徑視覺化工具為主,透過快速的視覺化呈現,再加上介面更加友善且易使用,改善傳統視覺化系統工具於網絡視覺化呈現上的不足。另一方面,以基因為主體,結合公開資料庫相關的基因本體論資訊、相關疾病分類等實用資訊,輔助使用者獲得更完整的訊息,以促使其研究工作得以更加順利的展開,以提升其研究使用上的效能及效率。
URI
https://203.71.86.71/handle/123456789/13300

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