Gene Variants of Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) and Risks of Ischemic Stroke in the Taiwanese Population.

It has been shown that stroke in the Icelandic population
may be attributed to gene variations in 5-lipoxygenaseactivating
protein (ALOX5AP) gene. Because the linkage
between the gene variations of these genes and ischemic
stroke in Taiwan has not been reported, we evaluated
whether ALOX5AP gene polymorphisms confers risk of
ischemic stoke in Taiwanese patients. Four singlenucleotide
polymorphisms (SNPs) covering the ALOX5AP
gene were genotyped using genomic DNA sequencing
and a high-throughput TaqMan PCR assay in 108 patients
suffering ischemic stroke and 280 healthy individuals.
No significant associations with ischemic stroke were
observed with SNPs HapA (SG13S32 and SG13S89) and
HapB (SG13S41 and SG13S35) from ALOX5AP, which
were a part of the Icelandic at-risk haplotypes. The
present data do not support a significant role for ALOX5AP
polymorphisms in a genetic susceptibility to ischemic
stroke in the Taiwanese population.