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  5. 弓形蟲感染的流行病學:奈及利亞奧桑州生育年齡 婦女之血清陽性率和相關危險因子
 
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弓形蟲感染的流行病學:奈及利亞奧桑州生育年齡 婦女之血清陽性率和相關危險因子

Other Title
Epidemiology of Toxoplasma gondii infection: Seroprevalence and associated risk factors for women of child-bearing age in Osun state, Nigeria
Type
thesis
Date Issued
2022-06-15
Author(s)
杜芸萱
Advisor
范家堃
Subjects
系所名稱:醫學科學研究所碩士班
Publisher
醫學科學研究所碩士班
Description
口試委員:范家堃 FAN, CHIA-KWUNG;鄭柏青 CHENG, PO-CHING;蕭信宏 SHIAO, SHIN-HONG
網際網路,開放日期為2022-07-21
Abstract
弓形蟲常見於貓科動物,是一種寄生在宿主細胞內的原生寄生蟲,會引發耳熟能詳的感染著——弓形蟲感染症(Toxoplasmosis),它是一種人和畜都共同的疾病,分佈範圍很廣並在世界各地都有許多感染者。由於先前的研究資料都缺乏對奈及利亞國之奧桑州的弓形蟲流行病學感染報告,所以目前我們仍然對於此地之生育年齡婦女的弓形蟲血清陽性率和相關可能的風險因子未知,所以本研究計劃從弓形蟲在當地之血清感染率與可能之疾病風險因子著手,探究奈及利亞國之生育年齡婦女的弓形蟲流行病學研究。本研究是一項社區性的橫斷式寄生蟲感染症研究,在2019年的5月到2019年12月,總共收集了415位年齡介於十八到四十九歲的生育年齡婦女之血液血清,並在實驗室透過弓形蟲抗體的酵素結合免疫吸附分析法(Enzyme-linked immunosorbent assay ,ELISA)來做感染篩檢並把結果數據做系統分析。本研究得出在此地區之育齡婦女的血清樣本中偵測出弓形蟲抗體IgG的血清陽性率高達76.63%,其中只有單一IgG為陽性並IgM為陰性的血清陽性率有44.10%,而IgG和IgM均為反應陽性的感染率為26.51%。能過代表急性感染與弓形蟲的生物抗體表達,單獨IgM為陽的血清感染率為6.02%。根據分析結果,與弓形蟲血清陽性率有顯著正比的風險因子為居住在鄉村地區(AOR = 0.39,CI:0.23-0.69)與宗教為伊斯蘭教的婦女(AOR = 4.71,CI:2.43-9.15),由此可鑒別出這兩個因子為弓形蟲感染症的危險因子之一。根據研究的綜合結果,應該提倡婦女在產前的門診追蹤時就對他們進行衛生健康教育,以便提升當地人對於弓形蟲感染症的了解和預防其傳播途徑的方法,從而減少孕婦及胎兒先天性感染弓形蟲的幾率。
URI
https://handle.ncl.edu.tw/11296/d93ehg
https://203.71.86.71/handle/123456789/10763

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