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Intra-articular injection of hyaluronate and indomethacin in rabbits with antigen-induced arthritis.
Type
article
Resource
Rheumatol Int.(27):1099-1111.
Date Issued
2007
Author(s)
梁有志
陳建和
Lo YJ
Sheu MT
Tsai WC
Lin YH
Li JL
Liang YC
Chang CC
Hsieh MS
Chen CH
Subjects
醫學檢驗暨生物技術學系
期刊論文
Abstract
Combined eVects of hyaluronate and indomethacin
in the treatment of rabbits with antigen-induced arthritis
(AIA) were evaluated by assessing joint swelling,
C-reactive protein (CRP) and prostaglandin E2 (PGE2)
levels with periodic intra-articular (ia) injections of hyaluronate
alone (HA group) and with either a low or high
concentration of indomethacin (LI-HA or HI-HA group).
End-point analyses included matrix metalloproteinases-3
(MMP-3) activity and macroscopic and histological joint
examinations. Results demonstrated that treatment in LI-HA
and HI-HA groups resulted in statistically signiWcant
suppression of CRP, PGE2, and MMP-3 in comparison with
those of HA group. Inhibition of serum CRP was only
observed in LI-HA group. The order of serum MMP-3
inhibition was LI-HA>HI-HA>HA. Based on macroscopic
and histological analyses of pannus formation, hyperplasia,
inXammation, joint leakage and erosion, and loss of proteoglycan,
the only statistically signiWcant improvement was
shown in LI-HA group compared to HA group and HI-HA
group compared to control group.
in the treatment of rabbits with antigen-induced arthritis
(AIA) were evaluated by assessing joint swelling,
C-reactive protein (CRP) and prostaglandin E2 (PGE2)
levels with periodic intra-articular (ia) injections of hyaluronate
alone (HA group) and with either a low or high
concentration of indomethacin (LI-HA or HI-HA group).
End-point analyses included matrix metalloproteinases-3
(MMP-3) activity and macroscopic and histological joint
examinations. Results demonstrated that treatment in LI-HA
and HI-HA groups resulted in statistically signiWcant
suppression of CRP, PGE2, and MMP-3 in comparison with
those of HA group. Inhibition of serum CRP was only
observed in LI-HA group. The order of serum MMP-3
inhibition was LI-HA>HI-HA>HA. Based on macroscopic
and histological analyses of pannus formation, hyperplasia,
inXammation, joint leakage and erosion, and loss of proteoglycan,
the only statistically signiWcant improvement was
shown in LI-HA group compared to HA group and HI-HA
group compared to control group.
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