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  5. 製備電紡奈米孔洞聚碸微管陣列薄膜應用於生物流體之處理程序
 
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製備電紡奈米孔洞聚碸微管陣列薄膜應用於生物流體之處理程序

Other Title
Fabrication of nano-porous Polysulfone(PSF) Microtube Array Membrane(MTAM) for bio-based fluid processing
Type
thesis
Date Issued
2016-07-01
Author(s)
楊三賢
Advisor
陳建中
Subjects
系所名稱:生醫材料暨組織工程研究所
Description
學位別:碩士
語文別:中文
指導教授:陳建中
共同指導教授:
口試委員:王權泉;張榮善
中文關鍵字:聚碸、多孔性、同軸靜電紡絲、奈米微管陣列薄膜
英文關鍵字:Polysulfone (PSF), porous, co-axial electrospinning, microtube array membranes (MTAMs)
Abstract
本實驗是利用同軸靜電紡絲技術,製備具有高順向性排列之聚碸微管陣列薄膜,其殼層紡絲液為聚碸(Polysufone, PSF)芯層紡絲液為聚乙二醇(Polyethylene glycol, PEG)聚氧化乙烯(Polyethylene glycol, PEO)混合溶液,加入不同濃度致孔劑聚乙烯?m咯烷酮(polyvinylpyrrolidone, PVP) 製備含有孔洞的中空纖維,而靜電紡絲微管陣列薄膜(MTAMs)具有管徑小、纖維直徑小、管壁薄、與更高的比表面積的結構特徵。本研究利用同軸靜電紡絲,製備出聚碸微管陣列薄膜(PSF MTAM)。以電子顯微鏡觀察其表面型態,可發現PSF MTAM,是由一根根微米級中空纖維緊密排列而成,且膜表面擁有奈米級的孔洞。PSF MTAM的管壁平均孔洞24.3±2.5nm,而微管平均截面積尺寸(長度與直徑)分別為72.33±4.71μm和56.46±6.21μm。薄膜平整度180±9.2°、薄膜機械強度8.6±0.4MPa、楊氏係數0.5±0.02 GPa、接觸角測定角度68±3°。初步生物流體處理應用結果發現,用於血漿過濾可有IgM 70±2%、IgG 17±5%、LDL 42±1%、HDL 10±1%的清除率。這個結果為顯示出PSF MTAMs在血漿過濾上具有發展的潛力。
URI
https://203.71.86.71/handle/123456789/57434

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