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  5. 空氣污染對睡眠呼吸障礙之相關性探討
 
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空氣污染對睡眠呼吸障礙之相關性探討

Other Title
Associations of air pollution with Sleep-disordered Breathing
Type
thesis
Date Issued
2015-06-15
Author(s)
沈彥伶
Advisor
莊凱任
Subjects
系所名稱:公共衛生學系暨研究所
Description
學位別:碩士
語文別:中文
指導教授:莊凱任
共同指導教授:
口試委員:吳章甫;劉文德
中文關鍵字:空氣污染;睡眠呼吸障礙
英文關鍵字:air pollution;sleep disordered breathing
Abstract
研究緣起:睡眠呼吸障礙(sleep-disordered breathing, SDB)是在徹夜發生多次呼吸部分或完全停止,以中華民國胸腔疾病醫學會調查的鼾聲(snoring)盛行率推估40歲以上的國人至少有3.44%罹患阻塞型睡眠呼吸中止(obstructive sleep apnea, OSA),但目前臺灣只有0.49%的就診率。而睡眠呼吸障礙及空氣污染分別會增加心血管疾病發生及死亡的風險,但目前兩者之間的相關性尚未被釐清。
研究目的:本研究利用臺北醫學大學附設醫院及衛生福利部雙和醫院的睡眠呼吸障礙患者來評估,是否空氣污染濃度上升會與26歲以上的睡眠呼吸障礙有相關性。
研究方法:利用2005年至2013年間經過整夜的睡眠多項生理檢查(polysomnography)得出的呼吸中止與淺呼吸指數(apnea and hypoxia index, AHI)及血氧飽和度降低指數(oxygen desaturation index, ODI)連結空氣污染監測站的逐時資料。空氣污染物指標包含粒徑小於等於10 μm之懸浮微粒(particles with aerodynamic diameters less than 10 μm, PM10)、粒徑小於等於2.5 μm之細懸浮微粒(particles with aerodynamic diameters less than 2.5 μm, PM2.5)、臭氧(ozone, O3)、一氧化碳(carbon monoxide, CO)、二氧化氮(nitrogen dioxide, NO2)、二氧化硫(sulfur dioxide, SO2)。所有的model分成短期:1-day, 3-day, 5-day average及長期:365-day average的空氣污染物濃度資料。
研究結果:呼吸中止與淺呼吸指數與短期及長期的污染物增加有相關性。而血氧飽和度降低指數除了長期臭氧外,皆與短期及長期的污染物增加有相關性。
結論:如果減少空氣污染的暴露會降低睡眠呼吸障礙的嚴重程度,並且可以改善心臟疾病的風險。
URI
https://203.71.86.71/handle/123456789/57021

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