表面處理混合粉末顆粒對鈦合金的生物相容性影響

In the present study, the influence of the discharge current in the
powder mixed electrical discharge machining (PMEDM) process on the
deposition of an electrical-discharge layer onto titanium-based alloys
(Ti–6Al–4V (Ti64)) as well as the influence of such a deposited
biocompatible electrical-discharge layer on MG-63 osteoblast-like cells
were investigated. An electrical-discharge layer was deposited on Ti64
specimens using a die-sinking electric discharge machine with titanium
dioxide (TiO2) powder suspended in distilled water. MG-63 cells were
cultured on untreated and PMEDM-treated specimens. Cell morphology
and metabolic activity were determined. PMEDM treatment roughened
the surface on a micro scale, whereas the nano-scale pores were
superimposed, accompanying with the increased TiO2 content. Cells
seeded on the PMEDM-15 surfaces showed that the cells were flattened
and well spread out and a significant increase in their proliferation on
PMEDM-treated surfaces as compared with those seeded on the untreated
surfaces. Our study revealed that the biological properties and
microstructure of the PMEDM-treated surfaces, including their chemical
composition and surface roughness, play important roles in their
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osteoblastic responses to the cultured specimens. These results can
provide insights into the development of new biomedical implant
surfaces.