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  5. Statin使用及到院前心跳停止病患預後之關聯性分析
 
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Statin使用及到院前心跳停止病患預後之關聯性分析

Other Title
Statin and Outcomes in Patients Presenting with Cardiac Arrest: A Nationwide Cohort Study
Type
thesis
Date Issued
2017-06-23
Author(s)
游秉勳
Advisor
湯澡薰
Subjects
系所名稱:醫務管理學研究所
Description
學位別:碩士
語文別:中文
指導教授:湯澡薰
口試委員:陳文鍾;陳怡樺
中文關鍵字:心跳停止;statin;一年存活
英文關鍵字:statin;cardiac arrest;one year survival
Abstract
研究目的:在冠心症、敗血症與缺血性中風發生前服用statin,對於疾病的預後有改善的效果。而突發性心跳停止的病患會有類似敗血症的的生理學反應。本文研究至急診時以心跳停止來表現的病患,是否在心跳停止前服用statin能改善其預後。

研究方法:本研究資料來源為『全民健康保險資料庫』全人口檔。以2004年至2011年資料庫篩選出在急診接受心肺復甦術的患者為分析對象,將病患分為在接受心肺復甦前30天連續使用statin與完全沒有使用statin兩群進行分析 。

研究結果:在使用傾向分數配對後的族群中,接受statin治療的患者,其一年存活率是沒有接受治療者的1.41倍(風險比=1.41,95%信賴區間=1.16-1.71,P≤0.01)。在次族群分析中,發現有糖尿病、慢性腎臟病與較高Charlson Comorbidity Index者,對於statin的治療特別的有反應。若在住院後停用statin,則其保護作用可能會變得不明顯。

結論:在心跳停止發先前30日使用statin,對於發生心跳停止的病患其預後有幫助,而此效果可以延續至一年,但若在住院後停用,則此保護作用可能會消失。

關鍵字:心跳停止、statin、一年存活
URI
https://203.71.86.71/handle/123456789/57861

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