Options
Interactive effects of essential and probably essential trace elements and lipid metabolism on metabolic syndrome in Taiwanese adults
Other Title
Interactive effects of essential and probably essential trace elements and lipid metabolism on metabolic syndrome in Taiwanese adults
Type
thesis
Date Issued
2023-07-13
Author(s)
PATCHARA SANGOPAS
Advisor
張榮素
Subjects
系所名稱：保健營養學系碩士班
Description
學位別：碩士
語文別：英文
口試委員：張榮素 CHANG, JUNG-SU;黃士懿 HUANG, SHIH-YI;蔡建松 TSAI, CHIEN-SUNG
授權範圍：網際網路,開放日期為2028-07-21
語文別：英文
口試委員：張榮素 CHANG, JUNG-SU;黃士懿 HUANG, SHIH-YI;蔡建松 TSAI, CHIEN-SUNG
授權範圍：網際網路,開放日期為2028-07-21
Abstract
Background: Obesity has become a widespread epidemic, affecting 13% of the global adult population. Recent studies have shown that essential or probably trace elements are associated with altered lipid metabolism and metabolic syndrome (MetS). However, mechanisms underlying this relationship remain unclear.
Aim: The purpose of this study was to investigate the association between essential or probably essentials trace elements and MetS with focus on lipid metabolites.
Methods: Anthropometric indices and blood biochemistry data of metabolic parameters were collected from 99 Taiwanese adults (normal weight: n=37, overweight/obese: n=27, morbid obese: n=35). Plasma metal profiles were assessed using inductively coupled plasma mass spectrometry and serum lipid species were performed using Ultra-performance liquid chromatography-mass spectrometry (UPLC-MS).
Results: Using Human metabolome database, a total of 161 lipid species was identified (p<0.05) from serum samples of 99 adults. Among the identified lipid species with variable importance in the projection (VIP) score >1, levels of Lysophosphatidylcholine (LysoPC) (O-18:0/0:0) and Monoglycerides (MG) (0:0/18:2/0:0) were significantly higher in morbid obese compared to normal weight and overweight/obese adults. PC species (pooled) showed a protective effect against MetS (OR=0.672 (0.534, 0.845), p<0.05), whilst, LysoPC species (pooled) exhibited strong risk effect on MetS (OR=1.35 (1.12, 1.64), p<0.05). Among individual lipid species, LysoPC(O-18:0/0:0) and MG(0:0/18:2/0:0) independently predicted MetS, OR=4.52 (2.48, 8.23) and OR=4.43 (2.41, 8.16), respectively (all p<0.05). Except Mg, essential metals such as Fe (OR= 3.27 (1.19, 9.00), Se (OR=15.37 (4.09, 57.80), Cr (OR= 5.912 (2.56, 13.68), Cu (OR=26.32 (5.12, 135.22), Mo (OR= 11.75 (3.51, 39.36), Ni (OR=1.96 (1.34, 2.86), Zn (OR=14.24 (2.97, 68.23) and Mn (OR=2.492 (1.014, 6.125) all independently predicted risk of MetS (all p<0.05), but effects were attenuated after further adjusted with BMI. Pearson correlation analysis showed strong to moderate positive correlations between (Law et al., 2019) and essential/probably essential trace elements Se, Cu, Zn, Ni, and Mo (all r > 0.5) but negative correlations between PC species and plasma levels of Ni, Se, and Cu (r > -0.4).
Conclusion: Increased exposure to essential/probably essential trace elements may increase risk of MetS, possibly through disrupting PC metabolic process.
Aim: The purpose of this study was to investigate the association between essential or probably essentials trace elements and MetS with focus on lipid metabolites.
Methods: Anthropometric indices and blood biochemistry data of metabolic parameters were collected from 99 Taiwanese adults (normal weight: n=37, overweight/obese: n=27, morbid obese: n=35). Plasma metal profiles were assessed using inductively coupled plasma mass spectrometry and serum lipid species were performed using Ultra-performance liquid chromatography-mass spectrometry (UPLC-MS).
Results: Using Human metabolome database, a total of 161 lipid species was identified (p<0.05) from serum samples of 99 adults. Among the identified lipid species with variable importance in the projection (VIP) score >1, levels of Lysophosphatidylcholine (LysoPC) (O-18:0/0:0) and Monoglycerides (MG) (0:0/18:2/0:0) were significantly higher in morbid obese compared to normal weight and overweight/obese adults. PC species (pooled) showed a protective effect against MetS (OR=0.672 (0.534, 0.845), p<0.05), whilst, LysoPC species (pooled) exhibited strong risk effect on MetS (OR=1.35 (1.12, 1.64), p<0.05). Among individual lipid species, LysoPC(O-18:0/0:0) and MG(0:0/18:2/0:0) independently predicted MetS, OR=4.52 (2.48, 8.23) and OR=4.43 (2.41, 8.16), respectively (all p<0.05). Except Mg, essential metals such as Fe (OR= 3.27 (1.19, 9.00), Se (OR=15.37 (4.09, 57.80), Cr (OR= 5.912 (2.56, 13.68), Cu (OR=26.32 (5.12, 135.22), Mo (OR= 11.75 (3.51, 39.36), Ni (OR=1.96 (1.34, 2.86), Zn (OR=14.24 (2.97, 68.23) and Mn (OR=2.492 (1.014, 6.125) all independently predicted risk of MetS (all p<0.05), but effects were attenuated after further adjusted with BMI. Pearson correlation analysis showed strong to moderate positive correlations between (Law et al., 2019) and essential/probably essential trace elements Se, Cu, Zn, Ni, and Mo (all r > 0.5) but negative correlations between PC species and plasma levels of Ni, Se, and Cu (r > -0.4).
Conclusion: Increased exposure to essential/probably essential trace elements may increase risk of MetS, possibly through disrupting PC metabolic process.