以BLAT為基礎的染色體轉位分析平台

染色體的一個片段由某一個位置移到另一個位置，稱為染色體轉位(Chromosome Translocation)。發生染色體轉位可能會造成慢性骨髓性白血病(chronic myeloid leukemia; CML)、伯奇氏淋巴瘤(Burkitt's lymphoma; BL)，腎臟亮細胞腫瘤(clear cell sarcoma of the kidney; CCSK)或其他疾病等。本研究以UCSC BLAT為基礎，建構了一個 web-based 的染色體轉位分析平台，由 UCSC BLAT 來提供快速的序列比對，並利用重組與分析，將單一物種或跨物種(包括human, mouse和rat)序列中的染色體轉位資訊找出。最後，經由單一物種或跨物種不同染色體中的序列組合並測試，測試結果顯示本研究確實能分析出單一物種或跨物種序列中具有染色體轉位的情況。
One part of chromosome from somewhere move to another place called ‘chromosome translocation’. This condition will cause chronic myeloid leukemia (CML), Burkitt's lymphoma (BL), clear cell sarcoma of the kidney (CCSK) or other diseases possibly. This study was based on UCSC BLAT and constructed a web-based analysis platform for chromosome translocation. It used UCSC BLAT to blast sequence rapidly and employed recombination and analysis to find the information of chromosome translocation at single organism or cross-species including human, mouse and rat organisms. Finally, the test using different chromosome sequences between single organism and cross-species are performed. The test results shown this system indeed found the conditions of chromosome translocation at single organism or cross-species.