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  5. 婦女子宮內膜異位患者呈現血中鋅、硒濃度降低的狀態
 
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婦女子宮內膜異位患者呈現血中鋅、硒濃度降低的狀態

Other Title
Decreasing blood concentration of zinc and selenium in patient with endometriosis
Type
thesis
Date Issued
2009-07-14
Author(s)
傅瓊琳
Advisor
葉錦瑩
Subjects
系所名稱:公共衛生學研究所
Description
學位別:碩士
語文別:中文
指導教授:葉錦瑩
共同指導教授:
口試委員:毛義方;曾啟瑞
中文關鍵字:子宮內膜異位;氧化壓力;硒;鋅;金屬
Abstract
子宮內膜異位症是子宮內膜出現在子宮腔外的現象,為育齡婦女常見的問題,且可影響生育力。近年來研究認為可能是環境因素作用所導致之表現型。國外研究顯示,來經較早、經期較短、行經期較長、經痛、瘦高體型、喝酒、咖啡、長時間使用子宮內避孕器及環境賀爾蒙等都是危險因子。這些因子是否導致氧化壓力造成細胞傷害,環境賀爾蒙是否干擾內分泌使危險性增加,都未獲釐清。本研究係探討子宮內膜異位的危險因子,及生活或環境中的暴露是否會影響人體的氧化壓力,進而造成子宮內膜異位。
本研究為橫斷研究法,共收取207個不孕症的初診個案。並排除先前已經過子宮內膜異位治療的婦女。收集個案之問卷,子宮內膜異位的判定結果,以及血液檢體進行脂質過氧化物質(MDA)、抗氧化能力(GSH)、金屬元素(Pb、Cd、Hg、Cr、Mn、Se、Cu、Zn、Fe)分析。
分析具有子宮內膜異位之個案EN(+)54位,不具有子宮內膜異位之個案EN(-)153位結果:婚姻狀況在EN(+)和EN(-)的分佈有達統計上的顯著差異,其餘的基本人口學資料皆未達統計上顯著差異。而月經狀況在EN(+)和EN(-)的分布也達統計上顯著差異。EN(+)在巧克力囊腫、人工流產(P=0.0180)以及經期不規則(P=0.0122)等達統計上顯著差異。
而氧化壓力的指標在EN(+)上,MDA的濃度較高,GSH的濃度較低。但皆未達統計上差異。本研究結果亦發現,子宮內膜異位婦女體內血中鋅、硒濃度顯著低於不具有子宮內膜異位的婦女。
URI
https://203.71.86.71/handle/123456789/12796
https://hdl.handle.net/11296/emahpv
File(s)
No Thumbnail Available
Name

C0191236.pdf

Size

11.4 MB

Format

Adobe PDF

Checksum

(MD5):99d217da0168aaf783b077ef40217372

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