陳志華莊爾元陳冠豪2026-05-062026-05-062025-01-10https://203.71.86.71/handle/123456789/9214學位別：博士 口試委員：林峻立; 張至宏; 楊正昌; 陳志華; 莊爾元 關鍵字：Osteoarthritis、Medial opening wedge high tibial osteotomy、Bulk metallic glass composite、Enhanced bone healingOsteoarthritis is a prevalent and debilitating medical condition, imposing a substantial burden on affected individuals. Among the prominent risk factors for knee osteoarthritis, varus knee deformity arising from lower limb axis deformities is a significant concern. Medial opening wedge high tibial osteotomy (MOWHTO) has emerged as an effective intervention for correcting varus knee malalignment, promoting cartilage regeneration, and attenuating the progression of osteoarthritis. Nevertheless, MOWHTO entails inherent risks, including lateral cortical hinge fractures, loss of correction, nonunion, and delayed union. In response to these challenges, this study investigates the potential of a bioabsorbable magnesium-based bulk metallic glass composite (Mg67Zn28Ca5 BMGC), enriched with molybdenum particles, as an innovative solution for MOWHTO. This research postulates that Mg67Zn28Ca5 BMGC, enhanced with molybdenum particles, exhibits superior mechanical properties and degradation profiles compared to conventional magnesium-based materials. Furthermore, we hypothesize that this composite creates an optimal microenvironment for bone growth through the gradual release of magnesium ions during degradation. Additionally, we propose that the incorporation of Mg67Zn28Ca5 BMGC with locking plate fixation in MOWHTO can enhance surgical stability and reduce stress concentrations, thereby mitigating the risks associated with correction loss and lateral hinge fractures. This synergistic study encompasses a comprehensive array of experiments, including the fabrication of Mg67Zn28Ca5 BMGC with molybdenum particles, mechanical property assessments, in vitro investigations involving degradation tests, cell viability assessments, cell migration assays, extracellular calcium deposition analyses, and evaluations of osteoblast differentiation. In vivo experiments were conducted using Mg67Zn28Ca5 BMGC rods to assess biological effects and bone growth within the material. Additionally, finite element analysis was employed to assess the mechanical impact of the Mg67Zn28Ca5 BMGC wedge in human MOWHTO, both before and after degradation. The results obtained demonstrate that Mg67Zn28Ca5 BMGC closely approximates the mechanical properties of human cortical bone, albeit with notable strength reduction upon immersion in simulated body fluid. Importantly, it exhibits a slower degradation rate compared to commercial magnesium alloys. In cellular studies, Mg67Zn28Ca5 BMGC outperforms existing materials in terms of cell viability, migration, osteoblastic differentiation, and calcium deposition. In vivo experiments revealed progressive degradation and absorption alongside bone ingrowth, underscoring excellent material integration with surrounding tissue. Finite element analysis validates the mechanical efficacy of the Mg67Zn28Ca5 BMGC wedge in MOWHTO. In conclusion, our research introduces a novel Mg67Zn28Ca5 BMGC augmented with molybdenum particles, possessing favorable mechanical and degradation characteristics. This composite holds promise for enhancing MOWHTO surgeries, closely aligning with the mechanical properties of human cortical bone, showcasing controlled degradation, and promoting the release of beneficial ions for bone health. The successful integration of this material into surrounding bone tissue suggests its suitability for high tibial osteotomy surgeries, offering a potential solution to enhance the outcomes of knee osteoarthritis patients.系所名稱：生醫材料暨組織工程研究所博士班thesis