吳慶榕原田文也2026-06-142026-06-142018-01-15https://203.71.86.71/handle/123456789/58083學位別：博士 語文別：英文 指導教授：吳慶榕 口試委員：陳彦州;張仲達;鄭景暉;沈永康 中文關鍵字：periodontitis, kidney, LPS, Porphyromonas gingivalis, microarray 英文關鍵字：periodontitis, kidney, LPS, Porphyromonas gingivalis, microarrayAlthough an association between periodontitis and chronic kidney disease (CKD) has been suggested, the mechanism involved remains unclear. Herein, we examined the global gene expression profile in a mouse model that showed no acute inflammation in the kidney following stimulation with lipopolysaccharides (LPS) derived from P. gingivalis (PG-LPS). The mice were injected with PG-LPS at a concentration of 5 mg/kg intraperitoneally, every 3 days, for one month. Microarray analysis was used to identify 10 genes with the highest expression levels in the kidney stimulated with PG-LPS. Among them, the functions of five genes (Saa3, Ticam2, Reg3b, Ocxt2a, and Xcr1) were known. The upregulation of these genes was confirmed by quantitative polymerase chain reaction assay. Furthermore, we examined whether the expression of these upregulated genes were altered in endothelial cells derived from the kidney, in vitro. The mRNA expression levels of all five genes were significantly higher in the experimental group than in the controls (no LPS stimulation; *p < 0.05). In conclusion, the responses noted in the kidney may have arisen mainly from the endothelial cells. Moreover, upregulation of the expression levels of Saa3, Ticam2, Reg3b, Ocxt2a, and Xcr1 may be associated with the pathogenesis of CKD.系所名稱：牙醫學系碩博士班thesis